Vcaps Plus: A Simpler Approach Yields a New Dimension in Performance

The chemical simplicity of Vcaps® Plus HPMC capsules, which contain just two primary components (HPMC and water), can yield important advantages. And because it is HPMC, there is a lower risk for interaction between the capsule and components of the formulation.

Elimination of Gelling Agents Reduces Interference with Analytical Assays

With no added gelling agents or ionic gel promoters, Vcaps Plus HPMC capsules can:

• Reduce interference with buffers used or in vitro dissolution studies
• Minimize interactions with dietary components of fed in vivo studies

In vitro Dissolution of caffeine in Vcaps® Plus capsules

Gelling System vs Vcaps® Plus

pH-Independent in vitro Dissolution

Vcaps Plus HPMC capsules offer prompt disintegration (3–4 minutes; USP Method).

In vitro studies provide dissolution end points that closely match gelatin capsules across the relevant pH range.

In vitro Dissolution Profiles

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Vcaps® Plus capsules